A high-throughput sequencing test for diagnosing inherited bleeding, thrombotic, and platelet disorders
Identifieur interne : 002466 ( Main/Exploration ); précédent : 002465; suivant : 002467A high-throughput sequencing test for diagnosing inherited bleeding, thrombotic, and platelet disorders
Auteurs : Ilenia Simeoni [Royaume-Uni] ; Jonathan C. Stephens [Royaume-Uni] ; Fengyuan Hu [Royaume-Uni] ; Sri V. V. Deevi [Royaume-Uni] ; Karyn Megy [Royaume-Uni] ; Tadbir K. Bariana [Royaume-Uni] ; Claire Lentaigne [Royaume-Uni] ; Sol Schulman [États-Unis] ; Suthesh Sivapalaratnam [Royaume-Uni] ; Minka J. A. Vries [Pays-Bas] ; Sarah K. Westbury [Royaume-Uni] ; Daniel Greene [Royaume-Uni] ; Sofia Papadia [Royaume-Uni] ; Marie-Christine Alessi [France] ; Antony P. Attwood [Royaume-Uni] ; Matthias Ballmaier [Allemagne] ; Gareth Baynam [Australie] ; Emilse Bermejo [Argentine] ; Marta Bertoli [Italie] ; Paul F. Bray [États-Unis] ; Loredana Bury [Italie] ; Marco Cattaneo [Italie] ; Peter Collins [Royaume-Uni] ; Louise C. Daugherty [Royaume-Uni] ; Rémi Favier [France] ; Deborah L. French [États-Unis] ; Bruce Furie [États-Unis] ; Michael Gattens [Royaume-Uni] ; Manuela Germeshausen [Allemagne] ; Cedric Ghevaert [Royaume-Uni] ; Anne C. Goodeve [Royaume-Uni] ; Jose A. Guerrero [Royaume-Uni] ; Daniel J. Hampshire [Royaume-Uni] ; Daniel P. Hart [Royaume-Uni] ; Johan W. M. Heemskerk [Pays-Bas] ; Yvonne M. C. Henskens [Pays-Bas] ; Marian Hill [Royaume-Uni] ; Nancy Hogg [Royaume-Uni] ; Jennifer D. Jolley [Royaume-Uni] ; Walter H. Kahr [Canada] ; Anne M. Kelly [Royaume-Uni] ; Ron Kerr [Royaume-Uni] ; Myrto Kostadima [Royaume-Uni] ; Shinji Kunishima [Japon] ; Michele P. Lambert [États-Unis] ; Ri Liesner [Royaume-Uni] ; José A. L Pez [États-Unis] ; Rutendo P. Mapeta [Royaume-Uni] ; Mary Mathias [Royaume-Uni] ; Carolyn M. Millar [Royaume-Uni] ; Amit Nathwani [Royaume-Uni] ; Marguerite Neerman-Arbez [Suisse] ; Alan T. Nurden [France] ; Paquita Nurden [France] ; Maha Othman [Canada] ; Kathelijne Peerlinck [Belgique] ; David J. Perry [Royaume-Uni] ; Pawan Poudel [Royaume-Uni] ; Pieter Reitsma [Pays-Bas] ; Matthew T. Rondina [États-Unis] ; Peter A. Smethurst [Royaume-Uni, Canada] ; William Stevenson [Australie] ; Artur Szkotak [Canada] ; Salih Tuna [Royaume-Uni] ; Christel Van Geet [Royaume-Uni] ; Deborah Whitehorn [Royaume-Uni] ; David A. Wilcox [États-Unis] ; Bin Zhang [États-Unis] ; Shoshana Revel-Vilk [Israël] ; Paolo Gresele [Italie] ; Daniel B. Bellissimo [États-Unis] ; Christopher J. Penkett [Royaume-Uni] ; Michael A. Laffan [Royaume-Uni] ; Andrew D. Mumford [Royaume-Uni] ; Augusto Rendon [Royaume-Uni] ; Keith Gomez [Royaume-Uni] ; Kathleen Freson [Royaume-Uni] ; Willem H. Ouwehand [Royaume-Uni] ; Ernest Turro [Royaume-Uni]Source :
- Blood [ 0006-4971 ] ; 2016.
Descripteurs français
- KwdFr :
- Analyse de séquence d'ADN (), Anomalies des plaquettes (génétique), Femelle, Humains, Hémorragie (génétique), Mutation, Mâle, Polymorphisme de nucléotide simple, Prédisposition génétique à une maladie, Séquençage nucléotidique à haut débit (), Thrombose (génétique), Variations de nombre de copies de segment d'ADN, Études cas-témoins, Études d'associations génétiques ().
- MESH :
- génétique : Anomalies des plaquettes, Hémorragie, Thrombose.
- Analyse de séquence d'ADN, Femelle, Humains, Mutation, Mâle, Polymorphisme de nucléotide simple, Prédisposition génétique à une maladie, Séquençage nucléotidique à haut débit, Variations de nombre de copies de segment d'ADN, Études cas-témoins, Études d'associations génétiques.
English descriptors
- KwdEn :
- Blood Platelet Disorders (genetics), Case-Control Studies, DNA Copy Number Variations, Female, Genetic Association Studies (methods), Genetic Predisposition to Disease, Hemorrhage (genetics), High-Throughput Nucleotide Sequencing (methods), Humans, Male, Mutation, Polymorphism, Single Nucleotide, Sequence Analysis, DNA (methods), Thrombosis (genetics).
- MESH :
- genetics : Blood Platelet Disorders, Hemorrhage, Thrombosis.
- methods : Genetic Association Studies, High-Throughput Nucleotide Sequencing, Sequence Analysis, DNA.
- Case-Control Studies, DNA Copy Number Variations, Female, Genetic Predisposition to Disease, Humans, Male, Mutation, Polymorphism, Single Nucleotide.
Abstract
Url:
DOI: 10.1182/blood-2015-12-688267
PubMed: 27084890
PubMed Central: 5016734
Affiliations:
- Allemagne, Argentine, Australie, Belgique, Canada, France, Israël, Italie, Japon, Pays-Bas, Royaume-Uni, Suisse, États-Unis
- Angleterre, Angleterre de l'Est, Basse-Saxe, Grand Londres, Hollande-Méridionale, Latium, Lombardie, Massachusetts, Nouvelle-Galles du Sud, Ohio, Ontario, Pennsylvanie, Provence-Alpes-Côte d'Azur, Utah, Washington (État), Wisconsin
- Cambridge, Hanovre, Leyde, Londres, Marseille, Milan, Rome, Sydney, Toronto
- Université de Cambridge, Université de Sydney, Université de Toronto
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Le document en format XML
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Stephens</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Haematology, University of Cambridge,</nlm:aff><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff2">National Institute for Health Research BioResource–Rare Diseases, Cambridge University Hospitals</nlm:aff><wicri:noCountry code="subfield">Cambridge University Hospitals</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3">National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Hu, Fengyuan" sort="Hu, Fengyuan" uniqKey="Hu F" first="Fengyuan" last="Hu">Fengyuan Hu</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Haematology, University of Cambridge,</nlm:aff><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4">Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Deevi, Sri V V" sort="Deevi, Sri V V" uniqKey="Deevi S" first="Sri V. V." last="Deevi">Sri V. V. Deevi</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Haematology, University of Cambridge,</nlm:aff><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff2">National Institute for Health Research BioResource–Rare Diseases, Cambridge University Hospitals</nlm:aff><wicri:noCountry code="subfield">Cambridge University Hospitals</wicri:noCountry></affiliation></author><author><name sortKey="Megy, Karyn" sort="Megy, Karyn" uniqKey="Megy K" first="Karyn" last="Megy">Karyn Megy</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Haematology, University of Cambridge,</nlm:aff><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff2">National Institute for Health Research BioResource–Rare Diseases, Cambridge University Hospitals</nlm:aff><wicri:noCountry code="subfield">Cambridge University Hospitals</wicri:noCountry></affiliation></author><author><name sortKey="Bariana, Tadbir K" sort="Bariana, Tadbir K" uniqKey="Bariana T" first="Tadbir K." last="Bariana">Tadbir K. Bariana</name><affiliation wicri:level="3"><nlm:aff id="aff5">The Katharine Dormandy Haemophilia Centre and Thrombosis Unit, Royal Free London National Health Service Foundation Trust, London, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Katharine Dormandy Haemophilia Centre and Thrombosis Unit, Royal Free London National Health Service Foundation Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff6">Department of Haematology, University College London Cancer Institute, London, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Haematology, University College London Cancer Institute, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Lentaigne, Claire" sort="Lentaigne, Claire" uniqKey="Lentaigne C" first="Claire" last="Lentaigne">Claire Lentaigne</name><affiliation><nlm:aff wicri:cut=", and" id="aff7">Centre for Haematology, Hammersmith Campus, Imperial College Academic Health Sciences Centre, Imperial College London</nlm:aff><wicri:noCountry code="subfield">Imperial College London</wicri:noCountry></affiliation><affiliation wicri:level="3"><nlm:aff id="aff8">Imperial College Healthcare National Health Service Trust, London, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Imperial College Healthcare National Health Service Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Schulman, Sol" sort="Schulman, Sol" uniqKey="Schulman S" first="Sol" last="Schulman">Sol Schulman</name><affiliation wicri:level="2"><nlm:aff id="aff9">Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Sivapalaratnam, Suthesh" sort="Sivapalaratnam, Suthesh" uniqKey="Sivapalaratnam S" first="Suthesh" last="Sivapalaratnam">Suthesh Sivapalaratnam</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Haematology, University of Cambridge,</nlm:aff><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3">National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="aff10">Department of Haematology, Barts Health National Health Service Trust, London, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Haematology, Barts Health National Health Service Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Vries, Minka J A" sort="Vries, Minka J A" uniqKey="Vries M" first="Minka J. A." last="Vries">Minka J. A. Vries</name><affiliation wicri:level="1"><nlm:aff id="aff11">Department of Biochemistry, Maastricht University, Maastricht, The Netherlands;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Biochemistry, Maastricht University, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Westbury, Sarah K" sort="Westbury, Sarah K" uniqKey="Westbury S" first="Sarah K." last="Westbury">Sarah K. Westbury</name><affiliation wicri:level="1"><nlm:aff id="aff12">School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Cellular and Molecular Medicine, University of Bristol, Bristol</wicri:regionArea><wicri:noRegion>Bristol</wicri:noRegion></affiliation></author><author><name sortKey="Greene, Daniel" sort="Greene, Daniel" uniqKey="Greene D" first="Daniel" last="Greene">Daniel Greene</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Haematology, University of Cambridge,</nlm:aff><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff2">National Institute for Health Research BioResource–Rare Diseases, Cambridge University Hospitals</nlm:aff><wicri:noCountry code="subfield">Cambridge University Hospitals</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="aff13">Medical Research Council Biostatistics Unit, Cambridge Institute of Public Health, Cambridge Biomedical Campus, Cambridge, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council Biostatistics Unit, Cambridge Institute of Public Health, Cambridge Biomedical Campus, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Papadia, Sofia" sort="Papadia, Sofia" uniqKey="Papadia S" first="Sofia" last="Papadia">Sofia Papadia</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Haematology, University of Cambridge,</nlm:aff><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff2">National Institute for Health Research BioResource–Rare Diseases, Cambridge University Hospitals</nlm:aff><wicri:noCountry code="subfield">Cambridge University Hospitals</wicri:noCountry></affiliation></author><author><name sortKey="Alessi, Marie Christine" sort="Alessi, Marie Christine" uniqKey="Alessi M" first="Marie-Christine" last="Alessi">Marie-Christine Alessi</name><affiliation wicri:level="3"><nlm:aff id="aff14">Institut National de la Santé et de la Recherche Médicale, Faculté de Médecine, Marseille, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé et de la Recherche Médicale, Faculté de Médecine, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Attwood, Antony P" sort="Attwood, Antony P" uniqKey="Attwood A" first="Antony P." last="Attwood">Antony P. Attwood</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Haematology, University of Cambridge,</nlm:aff><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff2">National Institute for Health Research BioResource–Rare Diseases, Cambridge University Hospitals</nlm:aff><wicri:noCountry code="subfield">Cambridge University Hospitals</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3">National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Ballmaier, Matthias" sort="Ballmaier, Matthias" uniqKey="Ballmaier M" first="Matthias" last="Ballmaier">Matthias Ballmaier</name><affiliation wicri:level="3"><nlm:aff id="aff15">Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Pediatric Hematology and Oncology, Hannover Medical School, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Baynam, Gareth" sort="Baynam, Gareth" uniqKey="Baynam G" first="Gareth" last="Baynam">Gareth Baynam</name><affiliation wicri:level="1"><nlm:aff id="aff16">School of Paediatrics and Child Health, The University of Western Australia, Crawley, Australia;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>School of Paediatrics and Child Health, The University of Western Australia, Crawley</wicri:regionArea><wicri:noRegion>Crawley</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff17">Western Australia Register of Developmental Anomalies, King Edward Memorial Hospital, Subiaco, Australia;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Western Australia Register of Developmental Anomalies, King Edward Memorial Hospital, Subiaco</wicri:regionArea><wicri:noRegion>Subiaco</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff18">Office of Population Health Genomics, WA Department of Health, East Perth, Australia;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Office of Population Health Genomics, WA Department of Health, East Perth</wicri:regionArea><wicri:noRegion>East Perth</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff19">Institute of Immunology and Infectious Diseases, Murdoch University, Murdoch, Australia;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Institute of Immunology and Infectious Diseases, Murdoch University, Murdoch</wicri:regionArea><wicri:noRegion>Murdoch</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff20">Telethon Kids Institute, Subiaco, Australia;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Telethon Kids Institute, Subiaco</wicri:regionArea><wicri:noRegion>Subiaco</wicri:noRegion></affiliation></author><author><name sortKey="Bermejo, Emilse" sort="Bermejo, Emilse" uniqKey="Bermejo E" first="Emilse" last="Bermejo">Emilse Bermejo</name><affiliation wicri:level="1"><nlm:aff id="aff21">Hematological Research Institute, National Academy of Medicine, Buenos Aires, Argentina;</nlm:aff><country xml:lang="fr">Argentine</country><wicri:regionArea>Hematological Research Institute, National Academy of Medicine, Buenos Aires</wicri:regionArea><wicri:noRegion>Buenos Aires</wicri:noRegion></affiliation></author><author><name sortKey="Bertoli, Marta" sort="Bertoli, Marta" uniqKey="Bertoli M" first="Marta" last="Bertoli">Marta Bertoli</name><affiliation wicri:level="3"><nlm:aff id="aff22">San Pietro Fatebenefratelli Hospital, Unita' Operativa Semplice Dipartimentale, Medical Genetics, Rome, Italy;</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>San Pietro Fatebenefratelli Hospital, Unita' Operativa Semplice Dipartimentale, Medical Genetics, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Bray, Paul F" sort="Bray, Paul F" uniqKey="Bray P" first="Paul F." last="Bray">Paul F. Bray</name><affiliation wicri:level="2"><nlm:aff id="aff23">Department of Medicine, Thomas Jefferson University, Jefferson Medical College, Philadelphia, PA;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Medicine, Thomas Jefferson University, Jefferson Medical College, Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Bury, Loredana" sort="Bury, Loredana" uniqKey="Bury L" first="Loredana" last="Bury">Loredana Bury</name><affiliation wicri:level="1"><nlm:aff id="aff24">Department of Internal Medicine, Section of Internal and Cardiovascular Medicine, University of Perugia, Perugia, Italy;</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Internal Medicine, Section of Internal and Cardiovascular Medicine, University of Perugia, Perugia</wicri:regionArea><wicri:noRegion>Perugia</wicri:noRegion></affiliation></author><author><name sortKey="Cattaneo, Marco" sort="Cattaneo, Marco" uniqKey="Cattaneo M" first="Marco" last="Cattaneo">Marco Cattaneo</name><affiliation wicri:level="3"><nlm:aff id="aff25">Dipartimento di Scienze Della Salute, Università Degli Studi di Milano, Unità di Medicina, Azienda Ospedaliera San Paolo, Milan, Italy;</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Scienze Della Salute, Università Degli Studi di Milano, Unità di Medicina, Azienda Ospedaliera San Paolo, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Collins, Peter" sort="Collins, Peter" uniqKey="Collins P" first="Peter" last="Collins">Peter Collins</name><affiliation wicri:level="1"><nlm:aff id="aff26">Arthur Bloom Haemophilia Centre, Institute of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Arthur Bloom Haemophilia Centre, Institute of Infection and Immunity, School of Medicine, Cardiff University, Cardiff</wicri:regionArea><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Daugherty, Louise C" sort="Daugherty, Louise C" uniqKey="Daugherty L" first="Louise C." last="Daugherty">Louise C. Daugherty</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Haematology, University of Cambridge,</nlm:aff><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff2">National Institute for Health Research BioResource–Rare Diseases, Cambridge University Hospitals</nlm:aff><wicri:noCountry code="subfield">Cambridge University Hospitals</wicri:noCountry></affiliation></author><author><name sortKey="Favier, Remi" sort="Favier, Remi" uniqKey="Favier R" first="Rémi" last="Favier">Rémi Favier</name><affiliation wicri:level="1"><nlm:aff id="aff27">Assistance Publique, Hôpitaux de Paris, Armand Trousseau Children Hospital, Paris, Inserm U1170, Villejuif, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Assistance Publique, Hôpitaux de Paris, Armand Trousseau Children Hospital, Paris, Inserm U1170, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="French, Deborah L" sort="French, Deborah L" uniqKey="French D" first="Deborah L." last="French">Deborah L. French</name><affiliation wicri:level="2"><nlm:aff id="aff28">Department of Pathology and Laboratory Medicine, Children’s Hospital of Philadelphia, Philadelphia, PA;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Pathology and Laboratory Medicine, Children’s Hospital of Philadelphia, Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Furie, Bruce" sort="Furie, Bruce" uniqKey="Furie B" first="Bruce" last="Furie">Bruce Furie</name><affiliation wicri:level="2"><nlm:aff id="aff9">Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Gattens, Michael" sort="Gattens, Michael" uniqKey="Gattens M" first="Michael" last="Gattens">Michael Gattens</name><affiliation wicri:level="1"><nlm:aff id="aff29">Department of Haematology, Addenbrooke’s Hospital, Cambridge University Hospitals National Health Service Foundation Trust, Cambridge Biomedical Campus, Cambridge, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Haematology, Addenbrooke’s Hospital, Cambridge University Hospitals National Health Service Foundation Trust, Cambridge Biomedical Campus, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Germeshausen, Manuela" sort="Germeshausen, Manuela" uniqKey="Germeshausen M" first="Manuela" last="Germeshausen">Manuela Germeshausen</name><affiliation wicri:level="3"><nlm:aff id="aff15">Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Pediatric Hematology and Oncology, Hannover Medical School, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Ghevaert, Cedric" sort="Ghevaert, Cedric" uniqKey="Ghevaert C" first="Cedric" last="Ghevaert">Cedric Ghevaert</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Haematology, University of Cambridge,</nlm:aff><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3">National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Goodeve, Anne C" sort="Goodeve, Anne C" uniqKey="Goodeve A" first="Anne C." last="Goodeve">Anne C. Goodeve</name><affiliation wicri:level="1"><nlm:aff id="aff30">Haemostasis Research Group, Department of Infection, Immunity and Cardiovascular Disease, Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Haemostasis Research Group, Department of Infection, Immunity and Cardiovascular Disease, Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield</wicri:regionArea><wicri:noRegion>Sheffield</wicri:noRegion></affiliation></author><author><name sortKey="Guerrero, Jose A" sort="Guerrero, Jose A" uniqKey="Guerrero J" first="Jose A." last="Guerrero">Jose A. Guerrero</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Haematology, University of Cambridge,</nlm:aff><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation></author><author><name sortKey="Hampshire, Daniel J" sort="Hampshire, Daniel J" uniqKey="Hampshire D" first="Daniel J." last="Hampshire">Daniel J. Hampshire</name><affiliation wicri:level="1"><nlm:aff id="aff30">Haemostasis Research Group, Department of Infection, Immunity and Cardiovascular Disease, Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Haemostasis Research Group, Department of Infection, Immunity and Cardiovascular Disease, Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield</wicri:regionArea><wicri:noRegion>Sheffield</wicri:noRegion></affiliation></author><author><name sortKey="Hart, Daniel P" sort="Hart, Daniel P" uniqKey="Hart D" first="Daniel P." last="Hart">Daniel P. Hart</name><affiliation wicri:level="3"><nlm:aff id="aff10">Department of Haematology, Barts Health National Health Service Trust, London, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Haematology, Barts Health National Health Service Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Heemskerk, Johan W M" sort="Heemskerk, Johan W M" uniqKey="Heemskerk J" first="Johan W. M." last="Heemskerk">Johan W. M. Heemskerk</name><affiliation wicri:level="1"><nlm:aff id="aff31">Department of Biochemistry, Cardiovascular Research Institute Maastricht, University of Maastricht, Maastricht, The Netherlands;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Biochemistry, Cardiovascular Research Institute Maastricht, University of Maastricht, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Henskens, Yvonne M C" sort="Henskens, Yvonne M C" uniqKey="Henskens Y" first="Yvonne M. C." last="Henskens">Yvonne M. C. Henskens</name><affiliation wicri:level="1"><nlm:aff id="aff11">Department of Biochemistry, Maastricht University, Maastricht, The Netherlands;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Biochemistry, Maastricht University, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Hill, Marian" sort="Hill, Marian" uniqKey="Hill M" first="Marian" last="Hill">Marian Hill</name><affiliation wicri:level="1"><nlm:aff id="aff32">Department of Clinical Pathology, Empath Pathology Services, Nottingham University Hospitals National Health Service Trust, Nottingham, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Clinical Pathology, Empath Pathology Services, Nottingham University Hospitals National Health Service Trust, Nottingham</wicri:regionArea><wicri:noRegion>Nottingham</wicri:noRegion></affiliation></author><author><name sortKey="Hogg, Nancy" sort="Hogg, Nancy" uniqKey="Hogg N" first="Nancy" last="Hogg">Nancy Hogg</name><affiliation wicri:level="3"><nlm:aff id="aff33">Cancer Research UK London Research Institute, London, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Research UK London Research Institute, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Jolley, Jennifer D" sort="Jolley, Jennifer D" uniqKey="Jolley J" first="Jennifer D." last="Jolley">Jennifer D. Jolley</name><affiliation wicri:level="1"><nlm:aff id="aff34">Components Development Laboratory, National Health Service Blood and Transplant, Cambridge, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Components Development Laboratory, National Health Service Blood and Transplant, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Kahr, Walter H" sort="Kahr, Walter H" uniqKey="Kahr W" first="Walter H." last="Kahr">Walter H. Kahr</name><affiliation wicri:level="4"><nlm:aff id="aff35">Department of Paediatrics, Division of Haematology/Oncology, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada;</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Paediatrics, Division of Haematology/Oncology, The Hospital for Sick Children, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Kelly, Anne M" sort="Kelly, Anne M" uniqKey="Kelly A" first="Anne M." last="Kelly">Anne M. Kelly</name><affiliation wicri:level="3"><nlm:aff id="aff36">Department of Haematology, Great Ormond Street Hospital for Children National Health Service Trust, London, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Haematology, Great Ormond Street Hospital for Children National Health Service Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Kerr, Ron" sort="Kerr, Ron" uniqKey="Kerr R" first="Ron" last="Kerr">Ron Kerr</name><affiliation wicri:level="1"><nlm:aff id="aff37">Department of Haematology, Ninewells Hospital, Dundee, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Haematology, Ninewells Hospital, Dundee</wicri:regionArea><wicri:noRegion>Dundee</wicri:noRegion></affiliation></author><author><name sortKey="Kostadima, Myrto" sort="Kostadima, Myrto" uniqKey="Kostadima M" first="Myrto" last="Kostadima">Myrto Kostadima</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Haematology, University of Cambridge,</nlm:aff><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff2">National Institute for Health Research BioResource–Rare Diseases, Cambridge University Hospitals</nlm:aff><wicri:noCountry code="subfield">Cambridge University Hospitals</wicri:noCountry></affiliation></author><author><name sortKey="Kunishima, Shinji" sort="Kunishima, Shinji" uniqKey="Kunishima S" first="Shinji" last="Kunishima">Shinji Kunishima</name><affiliation wicri:level="1"><nlm:aff id="aff38">Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Japan;</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya</wicri:regionArea><wicri:noRegion>Nagoya</wicri:noRegion></affiliation></author><author><name sortKey="Lambert, Michele P" sort="Lambert, Michele P" uniqKey="Lambert M" first="Michele P." last="Lambert">Michele P. Lambert</name><affiliation wicri:level="2"><nlm:aff id="aff28">Department of Pathology and Laboratory Medicine, Children’s Hospital of Philadelphia, Philadelphia, PA;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Pathology and Laboratory Medicine, Children’s Hospital of Philadelphia, Philadelphia</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="aff39">Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Liesner, Ri" sort="Liesner, Ri" uniqKey="Liesner R" first="Ri" last="Liesner">Ri Liesner</name><affiliation wicri:level="1"><nlm:aff id="aff37">Department of Haematology, Ninewells Hospital, Dundee, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Haematology, Ninewells Hospital, Dundee</wicri:regionArea><wicri:noRegion>Dundee</wicri:noRegion></affiliation></author><author><name sortKey="L Pez, Jose A" sort="L Pez, Jose A" uniqKey="L Pez J" first="José A." last="L Pez">José A. L Pez</name><affiliation wicri:level="2"><nlm:aff id="aff40">Puget Sound Blood Center, Research Institute, Seattle, WA;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Puget Sound Blood Center, Research Institute, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Mapeta, Rutendo P" sort="Mapeta, Rutendo P" uniqKey="Mapeta R" first="Rutendo P." last="Mapeta">Rutendo P. Mapeta</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Haematology, University of Cambridge,</nlm:aff><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff2">National Institute for Health Research BioResource–Rare Diseases, Cambridge University Hospitals</nlm:aff><wicri:noCountry code="subfield">Cambridge University Hospitals</wicri:noCountry></affiliation></author><author><name sortKey="Mathias, Mary" sort="Mathias, Mary" uniqKey="Mathias M" first="Mary" last="Mathias">Mary Mathias</name><affiliation wicri:level="1"><nlm:aff id="aff37">Department of Haematology, Ninewells Hospital, Dundee, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Haematology, Ninewells Hospital, Dundee</wicri:regionArea><wicri:noRegion>Dundee</wicri:noRegion></affiliation></author><author><name sortKey="Millar, Carolyn M" sort="Millar, Carolyn M" uniqKey="Millar C" first="Carolyn M." last="Millar">Carolyn M. Millar</name><affiliation><nlm:aff wicri:cut=", and" id="aff7">Centre for Haematology, Hammersmith Campus, Imperial College Academic Health Sciences Centre, Imperial College London</nlm:aff><wicri:noCountry code="subfield">Imperial College London</wicri:noCountry></affiliation><affiliation wicri:level="3"><nlm:aff id="aff8">Imperial College Healthcare National Health Service Trust, London, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Imperial College Healthcare National Health Service Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Nathwani, Amit" sort="Nathwani, Amit" uniqKey="Nathwani A" first="Amit" last="Nathwani">Amit Nathwani</name><affiliation wicri:level="3"><nlm:aff id="aff6">Department of Haematology, University College London Cancer Institute, London, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Haematology, University College London Cancer Institute, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Neerman Arbez, Marguerite" sort="Neerman Arbez, Marguerite" uniqKey="Neerman Arbez M" first="Marguerite" last="Neerman-Arbez">Marguerite Neerman-Arbez</name><affiliation wicri:level="1"><nlm:aff id="aff41">Department of Genetic Medicine and Development, University Medical Centre, Geneva, Switzerland;</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Genetic Medicine and Development, University Medical Centre, Geneva</wicri:regionArea><wicri:noRegion>Geneva</wicri:noRegion></affiliation></author><author><name sortKey="Nurden, Alan T" sort="Nurden, Alan T" uniqKey="Nurden A" first="Alan T." last="Nurden">Alan T. Nurden</name><affiliation wicri:level="1"><nlm:aff id="aff42">Institut Hospitalo-Universitaire LIRYC, Hôpital Xavier Arnozan, Pessac, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Hospitalo-Universitaire LIRYC, Hôpital Xavier Arnozan, Pessac</wicri:regionArea><wicri:noRegion>Pessac</wicri:noRegion><wicri:noRegion>Pessac</wicri:noRegion></affiliation></author><author><name sortKey="Nurden, Paquita" sort="Nurden, Paquita" uniqKey="Nurden P" first="Paquita" last="Nurden">Paquita Nurden</name><affiliation wicri:level="1"><nlm:aff id="aff42">Institut Hospitalo-Universitaire LIRYC, Hôpital Xavier Arnozan, Pessac, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Hospitalo-Universitaire LIRYC, Hôpital Xavier Arnozan, Pessac</wicri:regionArea><wicri:noRegion>Pessac</wicri:noRegion><wicri:noRegion>Pessac</wicri:noRegion></affiliation></author><author><name sortKey="Othman, Maha" sort="Othman, Maha" uniqKey="Othman M" first="Maha" last="Othman">Maha Othman</name><affiliation wicri:level="1"><nlm:aff id="aff43">Department of Biomedical and Molecular Sciences, School of Medicine, Queens University, Kingston, Ontario, Canada;</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Biomedical and Molecular Sciences, School of Medicine, Queens University, Kingston, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Peerlinck, Kathelijne" sort="Peerlinck, Kathelijne" uniqKey="Peerlinck K" first="Kathelijne" last="Peerlinck">Kathelijne Peerlinck</name><affiliation wicri:level="1"><nlm:aff id="aff44">Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, University of Leuven, Leuven, Belgium;</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, University of Leuven, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Perry, David J" sort="Perry, David J" uniqKey="Perry D" first="David J." last="Perry">David J. Perry</name><affiliation wicri:level="1"><nlm:aff id="aff29">Department of Haematology, Addenbrooke’s Hospital, Cambridge University Hospitals National Health Service Foundation Trust, Cambridge Biomedical Campus, Cambridge, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Haematology, Addenbrooke’s Hospital, Cambridge University Hospitals National Health Service Foundation Trust, Cambridge Biomedical Campus, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Poudel, Pawan" sort="Poudel, Pawan" uniqKey="Poudel P" first="Pawan" last="Poudel">Pawan Poudel</name><affiliation wicri:level="3"><nlm:aff id="aff45">Institute of Cancer Research, London, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cancer Research, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Reitsma, Pieter" sort="Reitsma, Pieter" uniqKey="Reitsma P" first="Pieter" last="Reitsma">Pieter Reitsma</name><affiliation wicri:level="3"><nlm:aff id="aff46">Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Rondina, Matthew T" sort="Rondina, Matthew T" uniqKey="Rondina M" first="Matthew T." last="Rondina">Matthew T. Rondina</name><affiliation wicri:level="2"><nlm:aff id="aff47">University of Utah School of Medicine, Eccles Institute of Human Genetics, Salt Lake City, UT;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Utah</region></placeName><wicri:cityArea>University of Utah School of Medicine, Eccles Institute of Human Genetics, Salt Lake City</wicri:cityArea></affiliation></author><author><name sortKey="Smethurst, Peter A" sort="Smethurst, Peter A" uniqKey="Smethurst P" first="Peter A." last="Smethurst">Peter A. Smethurst</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Haematology, University of Cambridge,</nlm:aff><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff35">Department of Paediatrics, Division of Haematology/Oncology, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada;</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Paediatrics, Division of Haematology/Oncology, The Hospital for Sick Children, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Stevenson, William" sort="Stevenson, William" uniqKey="Stevenson W" first="William" last="Stevenson">William Stevenson</name><affiliation wicri:level="1"><nlm:aff id="aff48">Department of Haematology and Transfusion Medicine, Royal North Shore Hospital, St. Leonards, NSW, Australia;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Haematology and Transfusion Medicine, Royal North Shore Hospital, St. Leonards, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="aff49">Kolling Institute of Medical Research, The University of Sydney, Sydney, Australia;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Kolling Institute of Medical Research, The University of Sydney, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Szkotak, Artur" sort="Szkotak, Artur" uniqKey="Szkotak A" first="Artur" last="Szkotak">Artur Szkotak</name><affiliation wicri:level="1"><nlm:aff id="aff50">Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada;</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta</wicri:regionArea><wicri:noRegion>Alberta</wicri:noRegion></affiliation></author><author><name sortKey="Tuna, Salih" sort="Tuna, Salih" uniqKey="Tuna S" first="Salih" last="Tuna">Salih Tuna</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Haematology, University of Cambridge,</nlm:aff><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff2">National Institute for Health Research BioResource–Rare Diseases, Cambridge University Hospitals</nlm:aff><wicri:noCountry code="subfield">Cambridge University Hospitals</wicri:noCountry></affiliation></author><author><name sortKey="Van Geet, Christel" sort="Van Geet, Christel" uniqKey="Van Geet C" first="Christel" last="Van Geet">Christel Van Geet</name><affiliation wicri:level="3"><nlm:aff id="aff45">Institute of Cancer Research, London, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cancer Research, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Whitehorn, Deborah" sort="Whitehorn, Deborah" uniqKey="Whitehorn D" first="Deborah" last="Whitehorn">Deborah Whitehorn</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Haematology, University of Cambridge,</nlm:aff><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff2">National Institute for Health Research BioResource–Rare Diseases, Cambridge University Hospitals</nlm:aff><wicri:noCountry code="subfield">Cambridge University Hospitals</wicri:noCountry></affiliation></author><author><name sortKey="Wilcox, David A" sort="Wilcox, David A" uniqKey="Wilcox D" first="David A." last="Wilcox">David A. Wilcox</name><affiliation wicri:level="2"><nlm:aff id="aff51">Children’s Hospital of Wisconsin Research Institute, Medical College of Wisconsin, Milwaukee, WI;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Wisconsin</region></placeName><wicri:cityArea>Children’s Hospital of Wisconsin Research Institute, Medical College of Wisconsin, Milwaukee</wicri:cityArea></affiliation></author><author><name sortKey="Zhang, Bin" sort="Zhang, Bin" uniqKey="Zhang B" first="Bin" last="Zhang">Bin Zhang</name><affiliation wicri:level="2"><nlm:aff id="aff52">Genomic Medicine Institute, Cleveland Clinic Lerner Research Institute, Cleveland, OH;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Genomic Medicine Institute, Cleveland Clinic Lerner Research Institute, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Revel Vilk, Shoshana" sort="Revel Vilk, Shoshana" uniqKey="Revel Vilk S" first="Shoshana" last="Revel-Vilk">Shoshana Revel-Vilk</name><affiliation wicri:level="1"><nlm:aff id="aff53">Pediatric Hematology/Oncology Department, Hadassah-Hebrew University Medical Center, Jerusalem, Israel;</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Pediatric Hematology/Oncology Department, Hadassah-Hebrew University Medical Center, Jerusalem</wicri:regionArea><wicri:noRegion>Jerusalem</wicri:noRegion></affiliation></author><author><name sortKey="Gresele, Paolo" sort="Gresele, Paolo" uniqKey="Gresele P" first="Paolo" last="Gresele">Paolo Gresele</name><affiliation wicri:level="1"><nlm:aff id="aff24">Department of Internal Medicine, Section of Internal and Cardiovascular Medicine, University of Perugia, Perugia, Italy;</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Internal Medicine, Section of Internal and Cardiovascular Medicine, University of Perugia, Perugia</wicri:regionArea><wicri:noRegion>Perugia</wicri:noRegion></affiliation></author><author><name sortKey="Bellissimo, Daniel B" sort="Bellissimo, Daniel B" uniqKey="Bellissimo D" first="Daniel B." last="Bellissimo">Daniel B. Bellissimo</name><affiliation wicri:level="2"><nlm:aff id="aff54">Clinical Genomics Laboratory, University of Pittsburgh, Pittsburgh, PA;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Clinical Genomics Laboratory, University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Penkett, Christopher J" sort="Penkett, Christopher J" uniqKey="Penkett C" first="Christopher J." last="Penkett">Christopher J. Penkett</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Haematology, University of Cambridge,</nlm:aff><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff2">National Institute for Health Research BioResource–Rare Diseases, Cambridge University Hospitals</nlm:aff><wicri:noCountry code="subfield">Cambridge University Hospitals</wicri:noCountry></affiliation></author><author><name sortKey="Laffan, Michael A" sort="Laffan, Michael A" uniqKey="Laffan M" first="Michael A." last="Laffan">Michael A. Laffan</name><affiliation><nlm:aff wicri:cut=", and" id="aff7">Centre for Haematology, Hammersmith Campus, Imperial College Academic Health Sciences Centre, Imperial College London</nlm:aff><wicri:noCountry code="subfield">Imperial College London</wicri:noCountry></affiliation><affiliation wicri:level="3"><nlm:aff id="aff8">Imperial College Healthcare National Health Service Trust, London, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Imperial College Healthcare National Health Service Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Mumford, Andrew D" sort="Mumford, Andrew D" uniqKey="Mumford A" first="Andrew D." last="Mumford">Andrew D. Mumford</name><affiliation wicri:level="1"><nlm:aff id="aff12">School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Cellular and Molecular Medicine, University of Bristol, Bristol</wicri:regionArea><wicri:noRegion>Bristol</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff55">School of Clinical Sciences, University of Bristol, Bristol, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Clinical Sciences, University of Bristol, Bristol</wicri:regionArea><wicri:noRegion>Bristol</wicri:noRegion></affiliation></author><author><name sortKey="Rendon, Augusto" sort="Rendon, Augusto" uniqKey="Rendon A" first="Augusto" last="Rendon">Augusto Rendon</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Haematology, University of Cambridge,</nlm:aff><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation><affiliation wicri:level="3"><nlm:aff wicri:cut="; and" id="aff56">Genomics England Limited, London, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Genomics England Limited, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Gomez, Keith" sort="Gomez, Keith" uniqKey="Gomez K" first="Keith" last="Gomez">Keith Gomez</name><affiliation wicri:level="3"><nlm:aff id="aff5">The Katharine Dormandy Haemophilia Centre and Thrombosis Unit, Royal Free London National Health Service Foundation Trust, London, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Katharine Dormandy Haemophilia Centre and Thrombosis Unit, Royal Free London National Health Service Foundation Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff6">Department of Haematology, University College London Cancer Institute, London, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Haematology, University College London Cancer Institute, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Freson, Kathleen" sort="Freson, Kathleen" uniqKey="Freson K" first="Kathleen" last="Freson">Kathleen Freson</name><affiliation wicri:level="3"><nlm:aff id="aff45">Institute of Cancer Research, London, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cancer Research, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Ouwehand, Willem H" sort="Ouwehand, Willem H" uniqKey="Ouwehand W" first="Willem H." last="Ouwehand">Willem H. Ouwehand</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Haematology, University of Cambridge,</nlm:aff><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff2">National Institute for Health Research BioResource–Rare Diseases, Cambridge University Hospitals</nlm:aff><wicri:noCountry code="subfield">Cambridge University Hospitals</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3">National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff57">Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Turro, Ernest" sort="Turro, Ernest" uniqKey="Turro E" first="Ernest" last="Turro">Ernest Turro</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Haematology, University of Cambridge,</nlm:aff><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff2">National Institute for Health Research BioResource–Rare Diseases, Cambridge University Hospitals</nlm:aff><wicri:noCountry code="subfield">Cambridge University Hospitals</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3">National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff13">Medical Research Council Biostatistics Unit, Cambridge Institute of Public Health, Cambridge Biomedical Campus, Cambridge, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council Biostatistics Unit, Cambridge Institute of Public Health, Cambridge Biomedical Campus, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27084890</idno><idno type="pmc">5016734</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016734</idno><idno type="RBID">PMC:5016734</idno><idno type="doi">10.1182/blood-2015-12-688267</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">001808</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001808</idno><idno type="wicri:Area/Pmc/Curation">001668</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001668</idno><idno type="wicri:Area/Pmc/Checkpoint">000B68</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000B68</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">001E05</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001E05</idno><idno type="wicri:Area/PubMed/Curation">001D81</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001D81</idno><idno type="wicri:Area/PubMed/Checkpoint">001D81</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001D81</idno><idno type="wicri:Area/Ncbi/Merge">003420</idno><idno type="wicri:Area/Ncbi/Curation">003420</idno><idno type="wicri:Area/Ncbi/Checkpoint">003420</idno><idno type="wicri:doubleKey">0006-4971:2016:Simeoni I:a:high:throughput</idno><idno type="wicri:Area/Main/Merge">002465</idno><idno type="wicri:Area/Main/Curation">002466</idno><idno type="wicri:Area/Main/Exploration">002466</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A high-throughput sequencing test for diagnosing inherited bleeding, thrombotic, and platelet disorders</title><author><name sortKey="Simeoni, Ilenia" sort="Simeoni, Ilenia" uniqKey="Simeoni I" first="Ilenia" last="Simeoni">Ilenia Simeoni</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Haematology, University of Cambridge,</nlm:aff><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff2">National Institute for Health Research BioResource–Rare Diseases, Cambridge University Hospitals</nlm:aff><wicri:noCountry code="subfield">Cambridge University Hospitals</wicri:noCountry></affiliation></author><author><name sortKey="Stephens, Jonathan C" sort="Stephens, Jonathan C" uniqKey="Stephens J" first="Jonathan C." last="Stephens">Jonathan C. Stephens</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Haematology, University of Cambridge,</nlm:aff><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff2">National Institute for Health Research BioResource–Rare Diseases, Cambridge University Hospitals</nlm:aff><wicri:noCountry code="subfield">Cambridge University Hospitals</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3">National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Hu, Fengyuan" sort="Hu, Fengyuan" uniqKey="Hu F" first="Fengyuan" last="Hu">Fengyuan Hu</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Haematology, University of Cambridge,</nlm:aff><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4">Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Deevi, Sri V V" sort="Deevi, Sri V V" uniqKey="Deevi S" first="Sri V. V." last="Deevi">Sri V. V. Deevi</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Haematology, University of Cambridge,</nlm:aff><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff2">National Institute for Health Research BioResource–Rare Diseases, Cambridge University Hospitals</nlm:aff><wicri:noCountry code="subfield">Cambridge University Hospitals</wicri:noCountry></affiliation></author><author><name sortKey="Megy, Karyn" sort="Megy, Karyn" uniqKey="Megy K" first="Karyn" last="Megy">Karyn Megy</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Haematology, University of Cambridge,</nlm:aff><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff2">National Institute for Health Research BioResource–Rare Diseases, Cambridge University Hospitals</nlm:aff><wicri:noCountry code="subfield">Cambridge University Hospitals</wicri:noCountry></affiliation></author><author><name sortKey="Bariana, Tadbir K" sort="Bariana, Tadbir K" uniqKey="Bariana T" first="Tadbir K." last="Bariana">Tadbir K. Bariana</name><affiliation wicri:level="3"><nlm:aff id="aff5">The Katharine Dormandy Haemophilia Centre and Thrombosis Unit, Royal Free London National Health Service Foundation Trust, London, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Katharine Dormandy Haemophilia Centre and Thrombosis Unit, Royal Free London National Health Service Foundation Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff6">Department of Haematology, University College London Cancer Institute, London, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Haematology, University College London Cancer Institute, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Lentaigne, Claire" sort="Lentaigne, Claire" uniqKey="Lentaigne C" first="Claire" last="Lentaigne">Claire Lentaigne</name><affiliation><nlm:aff wicri:cut=", and" id="aff7">Centre for Haematology, Hammersmith Campus, Imperial College Academic Health Sciences Centre, Imperial College London</nlm:aff><wicri:noCountry code="subfield">Imperial College London</wicri:noCountry></affiliation><affiliation wicri:level="3"><nlm:aff id="aff8">Imperial College Healthcare National Health Service Trust, London, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Imperial College Healthcare National Health Service Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Schulman, Sol" sort="Schulman, Sol" uniqKey="Schulman S" first="Sol" last="Schulman">Sol Schulman</name><affiliation wicri:level="2"><nlm:aff id="aff9">Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Sivapalaratnam, Suthesh" sort="Sivapalaratnam, Suthesh" uniqKey="Sivapalaratnam S" first="Suthesh" last="Sivapalaratnam">Suthesh Sivapalaratnam</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Haematology, University of Cambridge,</nlm:aff><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3">National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="aff10">Department of Haematology, Barts Health National Health Service Trust, London, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Haematology, Barts Health National Health Service Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Vries, Minka J A" sort="Vries, Minka J A" uniqKey="Vries M" first="Minka J. A." last="Vries">Minka J. A. Vries</name><affiliation wicri:level="1"><nlm:aff id="aff11">Department of Biochemistry, Maastricht University, Maastricht, The Netherlands;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Biochemistry, Maastricht University, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Westbury, Sarah K" sort="Westbury, Sarah K" uniqKey="Westbury S" first="Sarah K." last="Westbury">Sarah K. Westbury</name><affiliation wicri:level="1"><nlm:aff id="aff12">School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Cellular and Molecular Medicine, University of Bristol, Bristol</wicri:regionArea><wicri:noRegion>Bristol</wicri:noRegion></affiliation></author><author><name sortKey="Greene, Daniel" sort="Greene, Daniel" uniqKey="Greene D" first="Daniel" last="Greene">Daniel Greene</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Haematology, University of Cambridge,</nlm:aff><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff2">National Institute for Health Research BioResource–Rare Diseases, Cambridge University Hospitals</nlm:aff><wicri:noCountry code="subfield">Cambridge University Hospitals</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="aff13">Medical Research Council Biostatistics Unit, Cambridge Institute of Public Health, Cambridge Biomedical Campus, Cambridge, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council Biostatistics Unit, Cambridge Institute of Public Health, Cambridge Biomedical Campus, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Papadia, Sofia" sort="Papadia, Sofia" uniqKey="Papadia S" first="Sofia" last="Papadia">Sofia Papadia</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Haematology, University of Cambridge,</nlm:aff><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff2">National Institute for Health Research BioResource–Rare Diseases, Cambridge University Hospitals</nlm:aff><wicri:noCountry code="subfield">Cambridge University Hospitals</wicri:noCountry></affiliation></author><author><name sortKey="Alessi, Marie Christine" sort="Alessi, Marie Christine" uniqKey="Alessi M" first="Marie-Christine" last="Alessi">Marie-Christine Alessi</name><affiliation wicri:level="3"><nlm:aff id="aff14">Institut National de la Santé et de la Recherche Médicale, Faculté de Médecine, Marseille, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé et de la Recherche Médicale, Faculté de Médecine, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Attwood, Antony P" sort="Attwood, Antony P" uniqKey="Attwood A" first="Antony P." last="Attwood">Antony P. Attwood</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Haematology, University of Cambridge,</nlm:aff><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff2">National Institute for Health Research BioResource–Rare Diseases, Cambridge University Hospitals</nlm:aff><wicri:noCountry code="subfield">Cambridge University Hospitals</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3">National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Ballmaier, Matthias" sort="Ballmaier, Matthias" uniqKey="Ballmaier M" first="Matthias" last="Ballmaier">Matthias Ballmaier</name><affiliation wicri:level="3"><nlm:aff id="aff15">Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Pediatric Hematology and Oncology, Hannover Medical School, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Baynam, Gareth" sort="Baynam, Gareth" uniqKey="Baynam G" first="Gareth" last="Baynam">Gareth Baynam</name><affiliation wicri:level="1"><nlm:aff id="aff16">School of Paediatrics and Child Health, The University of Western Australia, Crawley, Australia;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>School of Paediatrics and Child Health, The University of Western Australia, Crawley</wicri:regionArea><wicri:noRegion>Crawley</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff17">Western Australia Register of Developmental Anomalies, King Edward Memorial Hospital, Subiaco, Australia;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Western Australia Register of Developmental Anomalies, King Edward Memorial Hospital, Subiaco</wicri:regionArea><wicri:noRegion>Subiaco</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff18">Office of Population Health Genomics, WA Department of Health, East Perth, Australia;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Office of Population Health Genomics, WA Department of Health, East Perth</wicri:regionArea><wicri:noRegion>East Perth</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff19">Institute of Immunology and Infectious Diseases, Murdoch University, Murdoch, Australia;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Institute of Immunology and Infectious Diseases, Murdoch University, Murdoch</wicri:regionArea><wicri:noRegion>Murdoch</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff20">Telethon Kids Institute, Subiaco, Australia;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Telethon Kids Institute, Subiaco</wicri:regionArea><wicri:noRegion>Subiaco</wicri:noRegion></affiliation></author><author><name sortKey="Bermejo, Emilse" sort="Bermejo, Emilse" uniqKey="Bermejo E" first="Emilse" last="Bermejo">Emilse Bermejo</name><affiliation wicri:level="1"><nlm:aff id="aff21">Hematological Research Institute, National Academy of Medicine, Buenos Aires, Argentina;</nlm:aff><country xml:lang="fr">Argentine</country><wicri:regionArea>Hematological Research Institute, National Academy of Medicine, Buenos Aires</wicri:regionArea><wicri:noRegion>Buenos Aires</wicri:noRegion></affiliation></author><author><name sortKey="Bertoli, Marta" sort="Bertoli, Marta" uniqKey="Bertoli M" first="Marta" last="Bertoli">Marta Bertoli</name><affiliation wicri:level="3"><nlm:aff id="aff22">San Pietro Fatebenefratelli Hospital, Unita' Operativa Semplice Dipartimentale, Medical Genetics, Rome, Italy;</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>San Pietro Fatebenefratelli Hospital, Unita' Operativa Semplice Dipartimentale, Medical Genetics, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Bray, Paul F" sort="Bray, Paul F" uniqKey="Bray P" first="Paul F." last="Bray">Paul F. Bray</name><affiliation wicri:level="2"><nlm:aff id="aff23">Department of Medicine, Thomas Jefferson University, Jefferson Medical College, Philadelphia, PA;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Medicine, Thomas Jefferson University, Jefferson Medical College, Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Bury, Loredana" sort="Bury, Loredana" uniqKey="Bury L" first="Loredana" last="Bury">Loredana Bury</name><affiliation wicri:level="1"><nlm:aff id="aff24">Department of Internal Medicine, Section of Internal and Cardiovascular Medicine, University of Perugia, Perugia, Italy;</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Internal Medicine, Section of Internal and Cardiovascular Medicine, University of Perugia, Perugia</wicri:regionArea><wicri:noRegion>Perugia</wicri:noRegion></affiliation></author><author><name sortKey="Cattaneo, Marco" sort="Cattaneo, Marco" uniqKey="Cattaneo M" first="Marco" last="Cattaneo">Marco Cattaneo</name><affiliation wicri:level="3"><nlm:aff id="aff25">Dipartimento di Scienze Della Salute, Università Degli Studi di Milano, Unità di Medicina, Azienda Ospedaliera San Paolo, Milan, Italy;</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Scienze Della Salute, Università Degli Studi di Milano, Unità di Medicina, Azienda Ospedaliera San Paolo, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Collins, Peter" sort="Collins, Peter" uniqKey="Collins P" first="Peter" last="Collins">Peter Collins</name><affiliation wicri:level="1"><nlm:aff id="aff26">Arthur Bloom Haemophilia Centre, Institute of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Arthur Bloom Haemophilia Centre, Institute of Infection and Immunity, School of Medicine, Cardiff University, Cardiff</wicri:regionArea><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Daugherty, Louise C" sort="Daugherty, Louise C" uniqKey="Daugherty L" first="Louise C." last="Daugherty">Louise C. Daugherty</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Haematology, University of Cambridge,</nlm:aff><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff2">National Institute for Health Research BioResource–Rare Diseases, Cambridge University Hospitals</nlm:aff><wicri:noCountry code="subfield">Cambridge University Hospitals</wicri:noCountry></affiliation></author><author><name sortKey="Favier, Remi" sort="Favier, Remi" uniqKey="Favier R" first="Rémi" last="Favier">Rémi Favier</name><affiliation wicri:level="1"><nlm:aff id="aff27">Assistance Publique, Hôpitaux de Paris, Armand Trousseau Children Hospital, Paris, Inserm U1170, Villejuif, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Assistance Publique, Hôpitaux de Paris, Armand Trousseau Children Hospital, Paris, Inserm U1170, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="French, Deborah L" sort="French, Deborah L" uniqKey="French D" first="Deborah L." last="French">Deborah L. French</name><affiliation wicri:level="2"><nlm:aff id="aff28">Department of Pathology and Laboratory Medicine, Children’s Hospital of Philadelphia, Philadelphia, PA;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Pathology and Laboratory Medicine, Children’s Hospital of Philadelphia, Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Furie, Bruce" sort="Furie, Bruce" uniqKey="Furie B" first="Bruce" last="Furie">Bruce Furie</name><affiliation wicri:level="2"><nlm:aff id="aff9">Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Gattens, Michael" sort="Gattens, Michael" uniqKey="Gattens M" first="Michael" last="Gattens">Michael Gattens</name><affiliation wicri:level="1"><nlm:aff id="aff29">Department of Haematology, Addenbrooke’s Hospital, Cambridge University Hospitals National Health Service Foundation Trust, Cambridge Biomedical Campus, Cambridge, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Haematology, Addenbrooke’s Hospital, Cambridge University Hospitals National Health Service Foundation Trust, Cambridge Biomedical Campus, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Germeshausen, Manuela" sort="Germeshausen, Manuela" uniqKey="Germeshausen M" first="Manuela" last="Germeshausen">Manuela Germeshausen</name><affiliation wicri:level="3"><nlm:aff id="aff15">Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Pediatric Hematology and Oncology, Hannover Medical School, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Ghevaert, Cedric" sort="Ghevaert, Cedric" uniqKey="Ghevaert C" first="Cedric" last="Ghevaert">Cedric Ghevaert</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Haematology, University of Cambridge,</nlm:aff><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3">National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Goodeve, Anne C" sort="Goodeve, Anne C" uniqKey="Goodeve A" first="Anne C." last="Goodeve">Anne C. Goodeve</name><affiliation wicri:level="1"><nlm:aff id="aff30">Haemostasis Research Group, Department of Infection, Immunity and Cardiovascular Disease, Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Haemostasis Research Group, Department of Infection, Immunity and Cardiovascular Disease, Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield</wicri:regionArea><wicri:noRegion>Sheffield</wicri:noRegion></affiliation></author><author><name sortKey="Guerrero, Jose A" sort="Guerrero, Jose A" uniqKey="Guerrero J" first="Jose A." last="Guerrero">Jose A. Guerrero</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Haematology, University of Cambridge,</nlm:aff><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation></author><author><name sortKey="Hampshire, Daniel J" sort="Hampshire, Daniel J" uniqKey="Hampshire D" first="Daniel J." last="Hampshire">Daniel J. Hampshire</name><affiliation wicri:level="1"><nlm:aff id="aff30">Haemostasis Research Group, Department of Infection, Immunity and Cardiovascular Disease, Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Haemostasis Research Group, Department of Infection, Immunity and Cardiovascular Disease, Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield</wicri:regionArea><wicri:noRegion>Sheffield</wicri:noRegion></affiliation></author><author><name sortKey="Hart, Daniel P" sort="Hart, Daniel P" uniqKey="Hart D" first="Daniel P." last="Hart">Daniel P. Hart</name><affiliation wicri:level="3"><nlm:aff id="aff10">Department of Haematology, Barts Health National Health Service Trust, London, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Haematology, Barts Health National Health Service Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Heemskerk, Johan W M" sort="Heemskerk, Johan W M" uniqKey="Heemskerk J" first="Johan W. M." last="Heemskerk">Johan W. M. Heemskerk</name><affiliation wicri:level="1"><nlm:aff id="aff31">Department of Biochemistry, Cardiovascular Research Institute Maastricht, University of Maastricht, Maastricht, The Netherlands;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Biochemistry, Cardiovascular Research Institute Maastricht, University of Maastricht, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Henskens, Yvonne M C" sort="Henskens, Yvonne M C" uniqKey="Henskens Y" first="Yvonne M. C." last="Henskens">Yvonne M. C. Henskens</name><affiliation wicri:level="1"><nlm:aff id="aff11">Department of Biochemistry, Maastricht University, Maastricht, The Netherlands;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Biochemistry, Maastricht University, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Hill, Marian" sort="Hill, Marian" uniqKey="Hill M" first="Marian" last="Hill">Marian Hill</name><affiliation wicri:level="1"><nlm:aff id="aff32">Department of Clinical Pathology, Empath Pathology Services, Nottingham University Hospitals National Health Service Trust, Nottingham, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Clinical Pathology, Empath Pathology Services, Nottingham University Hospitals National Health Service Trust, Nottingham</wicri:regionArea><wicri:noRegion>Nottingham</wicri:noRegion></affiliation></author><author><name sortKey="Hogg, Nancy" sort="Hogg, Nancy" uniqKey="Hogg N" first="Nancy" last="Hogg">Nancy Hogg</name><affiliation wicri:level="3"><nlm:aff id="aff33">Cancer Research UK London Research Institute, London, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Research UK London Research Institute, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Jolley, Jennifer D" sort="Jolley, Jennifer D" uniqKey="Jolley J" first="Jennifer D." last="Jolley">Jennifer D. Jolley</name><affiliation wicri:level="1"><nlm:aff id="aff34">Components Development Laboratory, National Health Service Blood and Transplant, Cambridge, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Components Development Laboratory, National Health Service Blood and Transplant, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Kahr, Walter H" sort="Kahr, Walter H" uniqKey="Kahr W" first="Walter H." last="Kahr">Walter H. Kahr</name><affiliation wicri:level="4"><nlm:aff id="aff35">Department of Paediatrics, Division of Haematology/Oncology, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada;</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Paediatrics, Division of Haematology/Oncology, The Hospital for Sick Children, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Kelly, Anne M" sort="Kelly, Anne M" uniqKey="Kelly A" first="Anne M." last="Kelly">Anne M. Kelly</name><affiliation wicri:level="3"><nlm:aff id="aff36">Department of Haematology, Great Ormond Street Hospital for Children National Health Service Trust, London, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Haematology, Great Ormond Street Hospital for Children National Health Service Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Kerr, Ron" sort="Kerr, Ron" uniqKey="Kerr R" first="Ron" last="Kerr">Ron Kerr</name><affiliation wicri:level="1"><nlm:aff id="aff37">Department of Haematology, Ninewells Hospital, Dundee, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Haematology, Ninewells Hospital, Dundee</wicri:regionArea><wicri:noRegion>Dundee</wicri:noRegion></affiliation></author><author><name sortKey="Kostadima, Myrto" sort="Kostadima, Myrto" uniqKey="Kostadima M" first="Myrto" last="Kostadima">Myrto Kostadima</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Haematology, University of Cambridge,</nlm:aff><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff2">National Institute for Health Research BioResource–Rare Diseases, Cambridge University Hospitals</nlm:aff><wicri:noCountry code="subfield">Cambridge University Hospitals</wicri:noCountry></affiliation></author><author><name sortKey="Kunishima, Shinji" sort="Kunishima, Shinji" uniqKey="Kunishima S" first="Shinji" last="Kunishima">Shinji Kunishima</name><affiliation wicri:level="1"><nlm:aff id="aff38">Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Japan;</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya</wicri:regionArea><wicri:noRegion>Nagoya</wicri:noRegion></affiliation></author><author><name sortKey="Lambert, Michele P" sort="Lambert, Michele P" uniqKey="Lambert M" first="Michele P." last="Lambert">Michele P. Lambert</name><affiliation wicri:level="2"><nlm:aff id="aff28">Department of Pathology and Laboratory Medicine, Children’s Hospital of Philadelphia, Philadelphia, PA;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Pathology and Laboratory Medicine, Children’s Hospital of Philadelphia, Philadelphia</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="aff39">Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Liesner, Ri" sort="Liesner, Ri" uniqKey="Liesner R" first="Ri" last="Liesner">Ri Liesner</name><affiliation wicri:level="1"><nlm:aff id="aff37">Department of Haematology, Ninewells Hospital, Dundee, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Haematology, Ninewells Hospital, Dundee</wicri:regionArea><wicri:noRegion>Dundee</wicri:noRegion></affiliation></author><author><name sortKey="L Pez, Jose A" sort="L Pez, Jose A" uniqKey="L Pez J" first="José A." last="L Pez">José A. L Pez</name><affiliation wicri:level="2"><nlm:aff id="aff40">Puget Sound Blood Center, Research Institute, Seattle, WA;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Puget Sound Blood Center, Research Institute, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Mapeta, Rutendo P" sort="Mapeta, Rutendo P" uniqKey="Mapeta R" first="Rutendo P." last="Mapeta">Rutendo P. Mapeta</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Haematology, University of Cambridge,</nlm:aff><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff2">National Institute for Health Research BioResource–Rare Diseases, Cambridge University Hospitals</nlm:aff><wicri:noCountry code="subfield">Cambridge University Hospitals</wicri:noCountry></affiliation></author><author><name sortKey="Mathias, Mary" sort="Mathias, Mary" uniqKey="Mathias M" first="Mary" last="Mathias">Mary Mathias</name><affiliation wicri:level="1"><nlm:aff id="aff37">Department of Haematology, Ninewells Hospital, Dundee, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Haematology, Ninewells Hospital, Dundee</wicri:regionArea><wicri:noRegion>Dundee</wicri:noRegion></affiliation></author><author><name sortKey="Millar, Carolyn M" sort="Millar, Carolyn M" uniqKey="Millar C" first="Carolyn M." last="Millar">Carolyn M. Millar</name><affiliation><nlm:aff wicri:cut=", and" id="aff7">Centre for Haematology, Hammersmith Campus, Imperial College Academic Health Sciences Centre, Imperial College London</nlm:aff><wicri:noCountry code="subfield">Imperial College London</wicri:noCountry></affiliation><affiliation wicri:level="3"><nlm:aff id="aff8">Imperial College Healthcare National Health Service Trust, London, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Imperial College Healthcare National Health Service Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Nathwani, Amit" sort="Nathwani, Amit" uniqKey="Nathwani A" first="Amit" last="Nathwani">Amit Nathwani</name><affiliation wicri:level="3"><nlm:aff id="aff6">Department of Haematology, University College London Cancer Institute, London, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Haematology, University College London Cancer Institute, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Neerman Arbez, Marguerite" sort="Neerman Arbez, Marguerite" uniqKey="Neerman Arbez M" first="Marguerite" last="Neerman-Arbez">Marguerite Neerman-Arbez</name><affiliation wicri:level="1"><nlm:aff id="aff41">Department of Genetic Medicine and Development, University Medical Centre, Geneva, Switzerland;</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Genetic Medicine and Development, University Medical Centre, Geneva</wicri:regionArea><wicri:noRegion>Geneva</wicri:noRegion></affiliation></author><author><name sortKey="Nurden, Alan T" sort="Nurden, Alan T" uniqKey="Nurden A" first="Alan T." last="Nurden">Alan T. Nurden</name><affiliation wicri:level="1"><nlm:aff id="aff42">Institut Hospitalo-Universitaire LIRYC, Hôpital Xavier Arnozan, Pessac, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Hospitalo-Universitaire LIRYC, Hôpital Xavier Arnozan, Pessac</wicri:regionArea><wicri:noRegion>Pessac</wicri:noRegion><wicri:noRegion>Pessac</wicri:noRegion></affiliation></author><author><name sortKey="Nurden, Paquita" sort="Nurden, Paquita" uniqKey="Nurden P" first="Paquita" last="Nurden">Paquita Nurden</name><affiliation wicri:level="1"><nlm:aff id="aff42">Institut Hospitalo-Universitaire LIRYC, Hôpital Xavier Arnozan, Pessac, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Hospitalo-Universitaire LIRYC, Hôpital Xavier Arnozan, Pessac</wicri:regionArea><wicri:noRegion>Pessac</wicri:noRegion><wicri:noRegion>Pessac</wicri:noRegion></affiliation></author><author><name sortKey="Othman, Maha" sort="Othman, Maha" uniqKey="Othman M" first="Maha" last="Othman">Maha Othman</name><affiliation wicri:level="1"><nlm:aff id="aff43">Department of Biomedical and Molecular Sciences, School of Medicine, Queens University, Kingston, Ontario, Canada;</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Biomedical and Molecular Sciences, School of Medicine, Queens University, Kingston, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Peerlinck, Kathelijne" sort="Peerlinck, Kathelijne" uniqKey="Peerlinck K" first="Kathelijne" last="Peerlinck">Kathelijne Peerlinck</name><affiliation wicri:level="1"><nlm:aff id="aff44">Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, University of Leuven, Leuven, Belgium;</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, University of Leuven, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Perry, David J" sort="Perry, David J" uniqKey="Perry D" first="David J." last="Perry">David J. Perry</name><affiliation wicri:level="1"><nlm:aff id="aff29">Department of Haematology, Addenbrooke’s Hospital, Cambridge University Hospitals National Health Service Foundation Trust, Cambridge Biomedical Campus, Cambridge, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Haematology, Addenbrooke’s Hospital, Cambridge University Hospitals National Health Service Foundation Trust, Cambridge Biomedical Campus, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Poudel, Pawan" sort="Poudel, Pawan" uniqKey="Poudel P" first="Pawan" last="Poudel">Pawan Poudel</name><affiliation wicri:level="3"><nlm:aff id="aff45">Institute of Cancer Research, London, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cancer Research, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Reitsma, Pieter" sort="Reitsma, Pieter" uniqKey="Reitsma P" first="Pieter" last="Reitsma">Pieter Reitsma</name><affiliation wicri:level="3"><nlm:aff id="aff46">Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Rondina, Matthew T" sort="Rondina, Matthew T" uniqKey="Rondina M" first="Matthew T." last="Rondina">Matthew T. Rondina</name><affiliation wicri:level="2"><nlm:aff id="aff47">University of Utah School of Medicine, Eccles Institute of Human Genetics, Salt Lake City, UT;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Utah</region></placeName><wicri:cityArea>University of Utah School of Medicine, Eccles Institute of Human Genetics, Salt Lake City</wicri:cityArea></affiliation></author><author><name sortKey="Smethurst, Peter A" sort="Smethurst, Peter A" uniqKey="Smethurst P" first="Peter A." last="Smethurst">Peter A. Smethurst</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Haematology, University of Cambridge,</nlm:aff><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff35">Department of Paediatrics, Division of Haematology/Oncology, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada;</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Paediatrics, Division of Haematology/Oncology, The Hospital for Sick Children, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Stevenson, William" sort="Stevenson, William" uniqKey="Stevenson W" first="William" last="Stevenson">William Stevenson</name><affiliation wicri:level="1"><nlm:aff id="aff48">Department of Haematology and Transfusion Medicine, Royal North Shore Hospital, St. Leonards, NSW, Australia;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Haematology and Transfusion Medicine, Royal North Shore Hospital, St. Leonards, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="aff49">Kolling Institute of Medical Research, The University of Sydney, Sydney, Australia;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Kolling Institute of Medical Research, The University of Sydney, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Szkotak, Artur" sort="Szkotak, Artur" uniqKey="Szkotak A" first="Artur" last="Szkotak">Artur Szkotak</name><affiliation wicri:level="1"><nlm:aff id="aff50">Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada;</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta</wicri:regionArea><wicri:noRegion>Alberta</wicri:noRegion></affiliation></author><author><name sortKey="Tuna, Salih" sort="Tuna, Salih" uniqKey="Tuna S" first="Salih" last="Tuna">Salih Tuna</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Haematology, University of Cambridge,</nlm:aff><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff2">National Institute for Health Research BioResource–Rare Diseases, Cambridge University Hospitals</nlm:aff><wicri:noCountry code="subfield">Cambridge University Hospitals</wicri:noCountry></affiliation></author><author><name sortKey="Van Geet, Christel" sort="Van Geet, Christel" uniqKey="Van Geet C" first="Christel" last="Van Geet">Christel Van Geet</name><affiliation wicri:level="3"><nlm:aff id="aff45">Institute of Cancer Research, London, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cancer Research, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Whitehorn, Deborah" sort="Whitehorn, Deborah" uniqKey="Whitehorn D" first="Deborah" last="Whitehorn">Deborah Whitehorn</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Haematology, University of Cambridge,</nlm:aff><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff2">National Institute for Health Research BioResource–Rare Diseases, Cambridge University Hospitals</nlm:aff><wicri:noCountry code="subfield">Cambridge University Hospitals</wicri:noCountry></affiliation></author><author><name sortKey="Wilcox, David A" sort="Wilcox, David A" uniqKey="Wilcox D" first="David A." last="Wilcox">David A. Wilcox</name><affiliation wicri:level="2"><nlm:aff id="aff51">Children’s Hospital of Wisconsin Research Institute, Medical College of Wisconsin, Milwaukee, WI;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Wisconsin</region></placeName><wicri:cityArea>Children’s Hospital of Wisconsin Research Institute, Medical College of Wisconsin, Milwaukee</wicri:cityArea></affiliation></author><author><name sortKey="Zhang, Bin" sort="Zhang, Bin" uniqKey="Zhang B" first="Bin" last="Zhang">Bin Zhang</name><affiliation wicri:level="2"><nlm:aff id="aff52">Genomic Medicine Institute, Cleveland Clinic Lerner Research Institute, Cleveland, OH;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Genomic Medicine Institute, Cleveland Clinic Lerner Research Institute, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Revel Vilk, Shoshana" sort="Revel Vilk, Shoshana" uniqKey="Revel Vilk S" first="Shoshana" last="Revel-Vilk">Shoshana Revel-Vilk</name><affiliation wicri:level="1"><nlm:aff id="aff53">Pediatric Hematology/Oncology Department, Hadassah-Hebrew University Medical Center, Jerusalem, Israel;</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Pediatric Hematology/Oncology Department, Hadassah-Hebrew University Medical Center, Jerusalem</wicri:regionArea><wicri:noRegion>Jerusalem</wicri:noRegion></affiliation></author><author><name sortKey="Gresele, Paolo" sort="Gresele, Paolo" uniqKey="Gresele P" first="Paolo" last="Gresele">Paolo Gresele</name><affiliation wicri:level="1"><nlm:aff id="aff24">Department of Internal Medicine, Section of Internal and Cardiovascular Medicine, University of Perugia, Perugia, Italy;</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Internal Medicine, Section of Internal and Cardiovascular Medicine, University of Perugia, Perugia</wicri:regionArea><wicri:noRegion>Perugia</wicri:noRegion></affiliation></author><author><name sortKey="Bellissimo, Daniel B" sort="Bellissimo, Daniel B" uniqKey="Bellissimo D" first="Daniel B." last="Bellissimo">Daniel B. Bellissimo</name><affiliation wicri:level="2"><nlm:aff id="aff54">Clinical Genomics Laboratory, University of Pittsburgh, Pittsburgh, PA;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Clinical Genomics Laboratory, University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Penkett, Christopher J" sort="Penkett, Christopher J" uniqKey="Penkett C" first="Christopher J." last="Penkett">Christopher J. Penkett</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Haematology, University of Cambridge,</nlm:aff><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff2">National Institute for Health Research BioResource–Rare Diseases, Cambridge University Hospitals</nlm:aff><wicri:noCountry code="subfield">Cambridge University Hospitals</wicri:noCountry></affiliation></author><author><name sortKey="Laffan, Michael A" sort="Laffan, Michael A" uniqKey="Laffan M" first="Michael A." last="Laffan">Michael A. Laffan</name><affiliation><nlm:aff wicri:cut=", and" id="aff7">Centre for Haematology, Hammersmith Campus, Imperial College Academic Health Sciences Centre, Imperial College London</nlm:aff><wicri:noCountry code="subfield">Imperial College London</wicri:noCountry></affiliation><affiliation wicri:level="3"><nlm:aff id="aff8">Imperial College Healthcare National Health Service Trust, London, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Imperial College Healthcare National Health Service Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Mumford, Andrew D" sort="Mumford, Andrew D" uniqKey="Mumford A" first="Andrew D." last="Mumford">Andrew D. Mumford</name><affiliation wicri:level="1"><nlm:aff id="aff12">School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Cellular and Molecular Medicine, University of Bristol, Bristol</wicri:regionArea><wicri:noRegion>Bristol</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff55">School of Clinical Sciences, University of Bristol, Bristol, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Clinical Sciences, University of Bristol, Bristol</wicri:regionArea><wicri:noRegion>Bristol</wicri:noRegion></affiliation></author><author><name sortKey="Rendon, Augusto" sort="Rendon, Augusto" uniqKey="Rendon A" first="Augusto" last="Rendon">Augusto Rendon</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Haematology, University of Cambridge,</nlm:aff><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation><affiliation wicri:level="3"><nlm:aff wicri:cut="; and" id="aff56">Genomics England Limited, London, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Genomics England Limited, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Gomez, Keith" sort="Gomez, Keith" uniqKey="Gomez K" first="Keith" last="Gomez">Keith Gomez</name><affiliation wicri:level="3"><nlm:aff id="aff5">The Katharine Dormandy Haemophilia Centre and Thrombosis Unit, Royal Free London National Health Service Foundation Trust, London, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Katharine Dormandy Haemophilia Centre and Thrombosis Unit, Royal Free London National Health Service Foundation Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff6">Department of Haematology, University College London Cancer Institute, London, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Haematology, University College London Cancer Institute, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Freson, Kathleen" sort="Freson, Kathleen" uniqKey="Freson K" first="Kathleen" last="Freson">Kathleen Freson</name><affiliation wicri:level="3"><nlm:aff id="aff45">Institute of Cancer Research, London, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cancer Research, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Ouwehand, Willem H" sort="Ouwehand, Willem H" uniqKey="Ouwehand W" first="Willem H." last="Ouwehand">Willem H. Ouwehand</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Haematology, University of Cambridge,</nlm:aff><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff2">National Institute for Health Research BioResource–Rare Diseases, Cambridge University Hospitals</nlm:aff><wicri:noCountry code="subfield">Cambridge University Hospitals</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3">National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff57">Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Turro, Ernest" sort="Turro, Ernest" uniqKey="Turro E" first="Ernest" last="Turro">Ernest Turro</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Haematology, University of Cambridge,</nlm:aff><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff2">National Institute for Health Research BioResource–Rare Diseases, Cambridge University Hospitals</nlm:aff><wicri:noCountry code="subfield">Cambridge University Hospitals</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3">National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff13">Medical Research Council Biostatistics Unit, Cambridge Institute of Public Health, Cambridge Biomedical Campus, Cambridge, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council Biostatistics Unit, Cambridge Institute of Public Health, Cambridge Biomedical Campus, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author></analytic><series><title level="j">Blood</title><idno type="ISSN">0006-4971</idno><idno type="eISSN">1528-0020</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Blood Platelet Disorders (genetics)</term><term>Case-Control Studies</term><term>DNA Copy Number Variations</term><term>Female</term><term>Genetic Association Studies (methods)</term><term>Genetic Predisposition to Disease</term><term>Hemorrhage (genetics)</term><term>High-Throughput Nucleotide Sequencing (methods)</term><term>Humans</term><term>Male</term><term>Mutation</term><term>Polymorphism, Single Nucleotide</term><term>Sequence Analysis, DNA (methods)</term><term>Thrombosis (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Analyse de séquence d'ADN ()</term><term>Anomalies des plaquettes (génétique)</term><term>Femelle</term><term>Humains</term><term>Hémorragie (génétique)</term><term>Mutation</term><term>Mâle</term><term>Polymorphisme de nucléotide simple</term><term>Prédisposition génétique à une maladie</term><term>Séquençage nucléotidique à haut débit ()</term><term>Thrombose (génétique)</term><term>Variations de nombre de copies de segment d'ADN</term><term>Études cas-témoins</term><term>Études d'associations génétiques ()</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Blood Platelet Disorders</term><term>Hemorrhage</term><term>Thrombosis</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Anomalies des plaquettes</term><term>Hémorragie</term><term>Thrombose</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Genetic Association Studies</term><term>High-Throughput Nucleotide Sequencing</term><term>Sequence Analysis, DNA</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Case-Control Studies</term><term>DNA Copy Number Variations</term><term>Female</term><term>Genetic Predisposition to Disease</term><term>Humans</term><term>Male</term><term>Mutation</term><term>Polymorphism, Single Nucleotide</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Analyse de séquence d'ADN</term><term>Femelle</term><term>Humains</term><term>Mutation</term><term>Mâle</term><term>Polymorphisme de nucléotide simple</term><term>Prédisposition génétique à une maladie</term><term>Séquençage nucléotidique à haut débit</term><term>Variations de nombre de copies de segment d'ADN</term><term>Études cas-témoins</term><term>Études d'associations génétiques</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><bold>Publisher's Note:</bold> There is an <related-article id="d36e1066" related-article-type="article-reference" ext-link-type="doi" xlink:href="10.1182/blood-2016-04-703215">Inside <italic>Blood</italic> Commentary</related-article> on this article in this issue.</p></div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Argentine</li><li>Australie</li><li>Belgique</li><li>Canada</li><li>France</li><li>Israël</li><li>Italie</li><li>Japon</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>Suisse</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Angleterre de l'Est</li><li>Basse-Saxe</li><li>Grand Londres</li><li>Hollande-Méridionale</li><li>Latium</li><li>Lombardie</li><li>Massachusetts</li><li>Nouvelle-Galles du Sud</li><li>Ohio</li><li>Ontario</li><li>Pennsylvanie</li><li>Provence-Alpes-Côte d'Azur</li><li>Utah</li><li>Washington (État)</li><li>Wisconsin</li></region><settlement><li>Cambridge</li><li>Hanovre</li><li>Leyde</li><li>Londres</li><li>Marseille</li><li>Milan</li><li>Rome</li><li>Sydney</li><li>Toronto</li></settlement><orgName><li>Université de Cambridge</li><li>Université de Sydney</li><li>Université de Toronto</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Simeoni, Ilenia" sort="Simeoni, Ilenia" uniqKey="Simeoni I" first="Ilenia" last="Simeoni">Ilenia Simeoni</name></region><name sortKey="Attwood, Antony P" sort="Attwood, Antony P" uniqKey="Attwood A" first="Antony P." last="Attwood">Antony P. Attwood</name><name sortKey="Attwood, Antony P" sort="Attwood, Antony P" uniqKey="Attwood A" first="Antony P." last="Attwood">Antony P. Attwood</name><name sortKey="Bariana, Tadbir K" sort="Bariana, Tadbir K" uniqKey="Bariana T" first="Tadbir K." last="Bariana">Tadbir K. Bariana</name><name sortKey="Bariana, Tadbir K" sort="Bariana, Tadbir K" uniqKey="Bariana T" first="Tadbir K." last="Bariana">Tadbir K. Bariana</name><name sortKey="Collins, Peter" sort="Collins, Peter" uniqKey="Collins P" first="Peter" last="Collins">Peter Collins</name><name sortKey="Daugherty, Louise C" sort="Daugherty, Louise C" uniqKey="Daugherty L" first="Louise C." last="Daugherty">Louise C. Daugherty</name><name sortKey="Deevi, Sri V V" sort="Deevi, Sri V V" uniqKey="Deevi S" first="Sri V. V." last="Deevi">Sri V. V. Deevi</name><name sortKey="Freson, Kathleen" sort="Freson, Kathleen" uniqKey="Freson K" first="Kathleen" last="Freson">Kathleen Freson</name><name sortKey="Gattens, Michael" sort="Gattens, Michael" uniqKey="Gattens M" first="Michael" last="Gattens">Michael Gattens</name><name sortKey="Ghevaert, Cedric" sort="Ghevaert, Cedric" uniqKey="Ghevaert C" first="Cedric" last="Ghevaert">Cedric Ghevaert</name><name sortKey="Ghevaert, Cedric" sort="Ghevaert, Cedric" uniqKey="Ghevaert C" first="Cedric" last="Ghevaert">Cedric Ghevaert</name><name sortKey="Gomez, Keith" sort="Gomez, Keith" uniqKey="Gomez K" first="Keith" last="Gomez">Keith Gomez</name><name sortKey="Gomez, Keith" sort="Gomez, Keith" uniqKey="Gomez K" first="Keith" last="Gomez">Keith Gomez</name><name sortKey="Goodeve, Anne C" sort="Goodeve, Anne C" uniqKey="Goodeve A" first="Anne C." last="Goodeve">Anne C. 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Hart</name><name sortKey="Hill, Marian" sort="Hill, Marian" uniqKey="Hill M" first="Marian" last="Hill">Marian Hill</name><name sortKey="Hogg, Nancy" sort="Hogg, Nancy" uniqKey="Hogg N" first="Nancy" last="Hogg">Nancy Hogg</name><name sortKey="Hu, Fengyuan" sort="Hu, Fengyuan" uniqKey="Hu F" first="Fengyuan" last="Hu">Fengyuan Hu</name><name sortKey="Hu, Fengyuan" sort="Hu, Fengyuan" uniqKey="Hu F" first="Fengyuan" last="Hu">Fengyuan Hu</name><name sortKey="Jolley, Jennifer D" sort="Jolley, Jennifer D" uniqKey="Jolley J" first="Jennifer D." last="Jolley">Jennifer D. Jolley</name><name sortKey="Kelly, Anne M" sort="Kelly, Anne M" uniqKey="Kelly A" first="Anne M." last="Kelly">Anne M. Kelly</name><name sortKey="Kerr, Ron" sort="Kerr, Ron" uniqKey="Kerr R" first="Ron" last="Kerr">Ron Kerr</name><name sortKey="Kostadima, Myrto" sort="Kostadima, Myrto" uniqKey="Kostadima M" first="Myrto" last="Kostadima">Myrto Kostadima</name><name sortKey="Laffan, Michael A" sort="Laffan, Michael A" uniqKey="Laffan M" first="Michael A." last="Laffan">Michael A. Laffan</name><name sortKey="Lentaigne, Claire" sort="Lentaigne, Claire" uniqKey="Lentaigne C" first="Claire" last="Lentaigne">Claire Lentaigne</name><name sortKey="Liesner, Ri" sort="Liesner, Ri" uniqKey="Liesner R" first="Ri" last="Liesner">Ri Liesner</name><name sortKey="Mapeta, Rutendo P" sort="Mapeta, Rutendo P" uniqKey="Mapeta R" first="Rutendo P." last="Mapeta">Rutendo P. Mapeta</name><name sortKey="Mathias, Mary" sort="Mathias, Mary" uniqKey="Mathias M" first="Mary" last="Mathias">Mary Mathias</name><name sortKey="Megy, Karyn" sort="Megy, Karyn" uniqKey="Megy K" first="Karyn" last="Megy">Karyn Megy</name><name sortKey="Millar, Carolyn M" sort="Millar, Carolyn M" uniqKey="Millar C" first="Carolyn M." last="Millar">Carolyn M. Millar</name><name sortKey="Mumford, Andrew D" sort="Mumford, Andrew D" uniqKey="Mumford A" first="Andrew D." last="Mumford">Andrew D. Mumford</name><name sortKey="Mumford, Andrew D" sort="Mumford, Andrew D" uniqKey="Mumford A" first="Andrew D." last="Mumford">Andrew D. Mumford</name><name sortKey="Nathwani, Amit" sort="Nathwani, Amit" uniqKey="Nathwani A" first="Amit" last="Nathwani">Amit Nathwani</name><name sortKey="Ouwehand, Willem H" sort="Ouwehand, Willem H" uniqKey="Ouwehand W" first="Willem H." last="Ouwehand">Willem H. 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Perry</name><name sortKey="Poudel, Pawan" sort="Poudel, Pawan" uniqKey="Poudel P" first="Pawan" last="Poudel">Pawan Poudel</name><name sortKey="Rendon, Augusto" sort="Rendon, Augusto" uniqKey="Rendon A" first="Augusto" last="Rendon">Augusto Rendon</name><name sortKey="Rendon, Augusto" sort="Rendon, Augusto" uniqKey="Rendon A" first="Augusto" last="Rendon">Augusto Rendon</name><name sortKey="Sivapalaratnam, Suthesh" sort="Sivapalaratnam, Suthesh" uniqKey="Sivapalaratnam S" first="Suthesh" last="Sivapalaratnam">Suthesh Sivapalaratnam</name><name sortKey="Sivapalaratnam, Suthesh" sort="Sivapalaratnam, Suthesh" uniqKey="Sivapalaratnam S" first="Suthesh" last="Sivapalaratnam">Suthesh Sivapalaratnam</name><name sortKey="Sivapalaratnam, Suthesh" sort="Sivapalaratnam, Suthesh" uniqKey="Sivapalaratnam S" first="Suthesh" last="Sivapalaratnam">Suthesh Sivapalaratnam</name><name sortKey="Smethurst, Peter A" sort="Smethurst, Peter A" uniqKey="Smethurst P" first="Peter A." last="Smethurst">Peter A. Smethurst</name><name sortKey="Stephens, Jonathan C" sort="Stephens, Jonathan C" uniqKey="Stephens J" first="Jonathan C." last="Stephens">Jonathan C. Stephens</name><name sortKey="Stephens, Jonathan C" sort="Stephens, Jonathan C" uniqKey="Stephens J" first="Jonathan C." last="Stephens">Jonathan C. Stephens</name><name sortKey="Tuna, Salih" sort="Tuna, Salih" uniqKey="Tuna S" first="Salih" last="Tuna">Salih Tuna</name><name sortKey="Turro, Ernest" sort="Turro, Ernest" uniqKey="Turro E" first="Ernest" last="Turro">Ernest Turro</name><name sortKey="Turro, Ernest" sort="Turro, Ernest" uniqKey="Turro E" first="Ernest" last="Turro">Ernest Turro</name><name sortKey="Turro, Ernest" sort="Turro, Ernest" uniqKey="Turro E" first="Ernest" last="Turro">Ernest Turro</name><name sortKey="Van Geet, Christel" sort="Van Geet, Christel" uniqKey="Van Geet C" first="Christel" last="Van Geet">Christel Van Geet</name><name sortKey="Westbury, Sarah K" sort="Westbury, Sarah K" uniqKey="Westbury S" first="Sarah K." last="Westbury">Sarah K. Westbury</name><name sortKey="Whitehorn, Deborah" sort="Whitehorn, Deborah" uniqKey="Whitehorn D" first="Deborah" last="Whitehorn">Deborah Whitehorn</name></country><country name="États-Unis"><region name="Massachusetts"><name sortKey="Schulman, Sol" sort="Schulman, Sol" uniqKey="Schulman S" first="Sol" last="Schulman">Sol Schulman</name></region><name sortKey="Bellissimo, Daniel B" sort="Bellissimo, Daniel B" uniqKey="Bellissimo D" first="Daniel B." last="Bellissimo">Daniel B. Bellissimo</name><name sortKey="Bray, Paul F" sort="Bray, Paul F" uniqKey="Bray P" first="Paul F." last="Bray">Paul F. Bray</name><name sortKey="French, Deborah L" sort="French, Deborah L" uniqKey="French D" first="Deborah L." last="French">Deborah L. French</name><name sortKey="Furie, Bruce" sort="Furie, Bruce" uniqKey="Furie B" first="Bruce" last="Furie">Bruce Furie</name><name sortKey="L Pez, Jose A" sort="L Pez, Jose A" uniqKey="L Pez J" first="José A." last="L Pez">José A. L Pez</name><name sortKey="Lambert, Michele P" sort="Lambert, Michele P" uniqKey="Lambert M" first="Michele P." last="Lambert">Michele P. Lambert</name><name sortKey="Lambert, Michele P" sort="Lambert, Michele P" uniqKey="Lambert M" first="Michele P." last="Lambert">Michele P. Lambert</name><name sortKey="Rondina, Matthew T" sort="Rondina, Matthew T" uniqKey="Rondina M" first="Matthew T." last="Rondina">Matthew T. Rondina</name><name sortKey="Wilcox, David A" sort="Wilcox, David A" uniqKey="Wilcox D" first="David A." last="Wilcox">David A. Wilcox</name><name sortKey="Zhang, Bin" sort="Zhang, Bin" uniqKey="Zhang B" first="Bin" last="Zhang">Bin Zhang</name></country><country name="Pays-Bas"><noRegion><name sortKey="Vries, Minka J A" sort="Vries, Minka J A" uniqKey="Vries M" first="Minka J. A." last="Vries">Minka J. A. Vries</name></noRegion><name sortKey="Heemskerk, Johan W M" sort="Heemskerk, Johan W M" uniqKey="Heemskerk J" first="Johan W. M." last="Heemskerk">Johan W. M. Heemskerk</name><name sortKey="Henskens, Yvonne M C" sort="Henskens, Yvonne M C" uniqKey="Henskens Y" first="Yvonne M. C." last="Henskens">Yvonne M. C. Henskens</name><name sortKey="Reitsma, Pieter" sort="Reitsma, Pieter" uniqKey="Reitsma P" first="Pieter" last="Reitsma">Pieter Reitsma</name></country><country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Alessi, Marie Christine" sort="Alessi, Marie Christine" uniqKey="Alessi M" first="Marie-Christine" last="Alessi">Marie-Christine Alessi</name></region><name sortKey="Favier, Remi" sort="Favier, Remi" uniqKey="Favier R" first="Rémi" last="Favier">Rémi Favier</name><name sortKey="Nurden, Alan T" sort="Nurden, Alan T" uniqKey="Nurden A" first="Alan T." last="Nurden">Alan T. Nurden</name><name sortKey="Nurden, Paquita" sort="Nurden, Paquita" uniqKey="Nurden P" first="Paquita" last="Nurden">Paquita Nurden</name></country><country name="Allemagne"><region name="Basse-Saxe"><name sortKey="Ballmaier, Matthias" sort="Ballmaier, Matthias" uniqKey="Ballmaier M" first="Matthias" last="Ballmaier">Matthias Ballmaier</name></region><name sortKey="Germeshausen, Manuela" sort="Germeshausen, Manuela" uniqKey="Germeshausen M" first="Manuela" last="Germeshausen">Manuela Germeshausen</name></country><country name="Australie"><noRegion><name sortKey="Baynam, Gareth" sort="Baynam, Gareth" uniqKey="Baynam G" first="Gareth" last="Baynam">Gareth Baynam</name></noRegion><name sortKey="Baynam, Gareth" sort="Baynam, Gareth" uniqKey="Baynam G" first="Gareth" last="Baynam">Gareth Baynam</name><name sortKey="Baynam, Gareth" sort="Baynam, Gareth" uniqKey="Baynam G" first="Gareth" last="Baynam">Gareth Baynam</name><name sortKey="Baynam, Gareth" sort="Baynam, Gareth" uniqKey="Baynam G" first="Gareth" last="Baynam">Gareth Baynam</name><name sortKey="Baynam, Gareth" sort="Baynam, Gareth" uniqKey="Baynam G" first="Gareth" last="Baynam">Gareth Baynam</name><name sortKey="Stevenson, William" sort="Stevenson, William" uniqKey="Stevenson W" first="William" last="Stevenson">William Stevenson</name><name sortKey="Stevenson, William" sort="Stevenson, William" uniqKey="Stevenson W" first="William" last="Stevenson">William Stevenson</name></country><country name="Argentine"><noRegion><name sortKey="Bermejo, Emilse" sort="Bermejo, Emilse" uniqKey="Bermejo E" first="Emilse" last="Bermejo">Emilse Bermejo</name></noRegion></country><country name="Italie"><region name="Latium"><name sortKey="Bertoli, Marta" sort="Bertoli, Marta" uniqKey="Bertoli M" first="Marta" last="Bertoli">Marta Bertoli</name></region><name sortKey="Bury, Loredana" sort="Bury, Loredana" uniqKey="Bury L" first="Loredana" last="Bury">Loredana Bury</name><name sortKey="Cattaneo, Marco" sort="Cattaneo, Marco" uniqKey="Cattaneo M" first="Marco" last="Cattaneo">Marco Cattaneo</name><name sortKey="Gresele, Paolo" sort="Gresele, Paolo" uniqKey="Gresele P" first="Paolo" last="Gresele">Paolo Gresele</name></country><country name="Canada"><region name="Ontario"><name sortKey="Kahr, Walter H" sort="Kahr, Walter H" uniqKey="Kahr W" first="Walter H." last="Kahr">Walter H. Kahr</name></region><name sortKey="Othman, Maha" sort="Othman, Maha" uniqKey="Othman M" first="Maha" last="Othman">Maha Othman</name><name sortKey="Smethurst, Peter A" sort="Smethurst, Peter A" uniqKey="Smethurst P" first="Peter A." last="Smethurst">Peter A. Smethurst</name><name sortKey="Szkotak, Artur" sort="Szkotak, Artur" uniqKey="Szkotak A" first="Artur" last="Szkotak">Artur Szkotak</name></country><country name="Japon"><noRegion><name sortKey="Kunishima, Shinji" sort="Kunishima, Shinji" uniqKey="Kunishima S" first="Shinji" last="Kunishima">Shinji Kunishima</name></noRegion></country><country name="Suisse"><noRegion><name sortKey="Neerman Arbez, Marguerite" sort="Neerman Arbez, Marguerite" uniqKey="Neerman Arbez M" first="Marguerite" last="Neerman-Arbez">Marguerite Neerman-Arbez</name></noRegion></country><country name="Belgique"><noRegion><name sortKey="Peerlinck, Kathelijne" sort="Peerlinck, Kathelijne" uniqKey="Peerlinck K" first="Kathelijne" last="Peerlinck">Kathelijne Peerlinck</name></noRegion></country><country name="Israël"><noRegion><name sortKey="Revel Vilk, Shoshana" sort="Revel Vilk, Shoshana" uniqKey="Revel Vilk S" first="Shoshana" last="Revel-Vilk">Shoshana Revel-Vilk</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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